The actin cytoskeleton is a key cellular structure subverted by pathogens to infect and survive in or on host cells. Several pathogenic strains of Escherichia coli, such as enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC), developed a unique mechanism to remodel the actin cytoskeleton that involves the assembly of actin filament‐rich pedestals beneath the bacterial attachment sites. Actin pedestal assembly is driven by bacterial effectors injected into the host cells, and this structure is important for EPEC and EHEC (...) colonization. While the interplay between bacterial effectors and the actin polymerization machinery of host cells is well‐understood, how other mechanisms of actin filament remodelling regulate pedestal assembly and bacterial attachment are poorly investigated. This review discusses the gaps in our understanding of the complexity of the actin cytoskeletal remodelling during EPEC and EHEC infection. We describe possible roles of actin depolymerizing, crosslinking and motor proteins in pedestal dynamics, and bacterial interactions with the host cells. We also discuss the biological significance of pedestal assembly for bacterial infection. (shrink)

Do perceiving subjects represent kind properties in the content of their conscious visual experience when they see and recognize instances of those natural kinds? In Part 1 of my thesis I clarify this question, in Part 2 I answer it, and in Part 3 I raise a problem for previous answers. Part 1 conceives of conscious experience in an internalist way, and the unified conscious episode does not exclude having beliefs about what one sees. Following Siegel and Bayne, Part 2 (...) formulates two arguments in support of representing kind properties in the content of experience. In Part 3, I argue that attempts to distinguish visual experiences from visual beliefs might fail to account for the interplay of sensory and cognitive elements in visual object recognition. I conclude by suggesting it has not been established that visual experiences can be distinguished from visual beliefs. (shrink)

The paper is devoted to Nikolay Lossky who was one of the leading Russian philosophers of the first half of the twentieth century. We demonstrate the interrelationship between three aspects of Lossky’s philosophy: realism in the theory of knowledge, hierarchical personalism, and supra-naturalistic concept of evolution. We pay attention to the contemporary relevance of Lossky, and we discuss and critique his ideas in light of those of other philosophers. Lossky acknowledges that the subject interacts with being itself and that knowledge (...) is not a shadow or copy of being. His ontology is based on intuitivism and epistemological optimism. Its main categories are God, as the super-systematic principle, and monads. In Lossky’s metaphysics, the idea of abstract ideal principles of being is quite harmoniously combined with personalism. Lossky’s ontology has strong ethical underpinnings. He considers that values are rooted in being and that the evolution of the world is directed by God towards the good. Lossky elaborates a supra-naturalistic concept of evolution. He extrapolates principles of teleological determination, which are fundamental to human existence, on the underlying levels of the world as a whole. Many trends of modern thought are in tune with Lossky’s philosophy, including a return to metaphysics, panpsychism, Platonism, and the desire to unite the religious worldview with new scientific discoveries. (shrink)

When the language-dominant hemisphere is damaged by a focal lesion, the brain may reorganize the language network through functional and structural changes known as adaptive plasticity. Adaptive plasticity is documented for triggers including ischemic, tumoral, and epileptic focal lesions, with effects in clinical practice. Many questions remain regarding language plasticity. Different lesions may induce different patterns of reorganization depending on pathologic features, location in the brain, and timing of onset. Neuroimaging provides insights into language plasticity due to its non-invasiveness, ability (...) to image the whole brain, and large-scale implementation. This review provides an overview of language plasticity on MRI with insights for patient care. First, we describe the structural and functional language network as depicted by neuroimaging. Second, we explore language reorganization triggered by stroke, brain tumors, and epileptic lesions and analyze applications in clinical diagnosis and treatment planning. By comparing different focal lesions, we investigate determinants of language plasticity including lesion location and timing of onset, longitudinal evolution of reorganization, and the relationship between structural and functional changes. (shrink)

Naïve realists have a motive to but have thus far been unable to offer compelling reasons for positing an external constraint on the occurrence of the consciousness involved in perfect hallucinations. If the occurrences of such consciousness were confined to abnormal perceptual contexts, the possibility of perfect hallucinations would have no bearing on the nature of the consciousness involved in cases of perception. On the other hand, it is unclear why the character of the perceptual context should matter constitutively to (...) the occurrence of the sort of consciousness involved in perfect hallucinations. Supposing (reasonably) that such consciousness does not consist in an awareness of the environment, it is puzzling why the latter should be a certain way for the former to occur. I propose a solution to this puzzle, which helps secure the naïve realist approach to perception. Perfect hallucinatory experiences issue from exercises of the perceptual system operating in a second, defective mode – complementary to the normal one, whose exercises issue in an awareness of the environment. (shrink)

Is property-awareness constituted by representation or not? If it were, merely being aware of the qualities of physical objects would involve being in a representational state. This would have considerable implications for a prominent view of the nature of successful perceptual experiences. According to naïve realism, any such experience—or more specifically its character—is fundamentally a relation of awareness to concrete items in the environment. Naïve realists take their view to be a genuine alternative to representationalism, the view on which the (...) character of such experiences is constituted by representation. But naïve realists must admit qualities or property instances as items of awareness if they are to remain wedded to common sense, and the nature of property-awareness may smuggle constitutive representation into the naïve realist account of character. I argue that whether property-awareness involves representation, and consequently whether naïve realism is distinct from representationalism or not, depends on what qualities are fundamentally. On universalist and nominalist accounts, property-awareness turns out to involve representation. Not so under tropism. (shrink)

1. Aretè : idei i obrazi v sbornata dobrodetelnost -- 2. Aretè : ekzistent︠s︡ialno-t︠s︡ennostna sistema -- 3. Aretè : obuchenie i vŭzpitanie na lidera -- 4. Aretè : upravlenie na dŭrzhavnostta i sigurnostta -- 5. Aretè v muzei︠a︡ : razvitie v strukturata i upravlenieto na evropeĭskii︠a︡ istoricheski muzeĭ -- 6. Avtoreferat na Aretè-logii︠a︡ : knigi I-V.

I argue that an analogy between pains and sounds suggests a way to give an objective account of pain which fits well with a naïve perceptualist account of feeling pain. According to the proposed metaphysical account, pains are relational physical events with shared qualitative nature, each of which is constituted by tissue damage and the activation of nociceptors. I proceed to show that the metaphysical proposal is compatible with platitudes about pains being animate, private, and self-intimating states.

Russian idea as philosophy of longing future of Russia was formed by humanists in opposition to real state of life in the country. Beginning from Moscow kingdom in Russia there were often oppression, injustice, loutishness, bribery, cultural backwardness, lack of education. The number of civilized, highly educated, high-moral people was very narrow. But the part they played in the history was extremely great; they were always the social vanguard of our motherland. They themselves brought really human properties for their country, (...) which would be developed later and would be discovered in the lives of majority of the population of our country. What is really human or simply human in opposition to inhuman in a person? Everything is very simple. Good will in people appears when they begin to follow the commandments: don’t kill, don’t tempt, don’t steal, don’t use foul language etc. And vice versa, if a person breaks these rules, he loses his humanity. Its essence is simple; the main idea is that it is important for the highest moral principles to become the attribute of life for the majority of people in the country, just like mobile phone or computer became an integral part of people’s life today. Today Russian idea becomes global one. One cannot use other people for achieving their goals. It means that while different nations and states treat each other cautiously and suspiciously, with secret desire to gain something by deception, to acquire something fraudulently, to make a fortune by fraud, none of global problems will be solved positively. (shrink)

In the system of the philosophical and sociological ideas of the Frankfurt School the "critical theory" of society occupies the central place. In the "critical theory" are interwoven all the most significant aspects of the philosophical, economic, political, sociological, psychological, aesthetic, and ethical ideas dealt with by the representatives of this school. And therefore it is not accidental that the concept of the "critical theory" of society is employed frequently as a synonym of the social philosophy of the Frankfurt School. (...) The multi-leveled problematique of the "critical theory" of society, and the contradictoriness of the theoretical positions of its adherents, complicate critical analysis. Therefore, the explanation of its methodological orientation, which can help us to understand better the existence and actual philosophical nature of this theory, has important significance for our discussion. (shrink)

I propose that the fundamental challenge Berkeley left realists is to account for experiences’ ability to present items as mind-independent, consistent with the claim that experiences always present themselves among the items of awareness. By exploring two ways of responding to this challenge, and ruling out the second, I hope to show that realists aiming to secure a role for experiences in grounding our grasp of mind-independence need to adopt a specific view of perceptual experience. They must take experiences to (...) have translucent aspects, and accord such aspects an essential role in presenting us with a mind-independent world. (shrink)

The articles discusses the philosophical foundations and the traditions of the theory of the humanitarian and technological revolution. The subject-matter of HTR theory is the description and forecast of the transition from the industrial to the post-industrial phase of civilization development as well as the strategy and the most effective methods of management of various socio-economic systems. This theory, actively developing in recent years, focuses on goal setting and on determining priorities and development criteria in the field of technology, science (...) and education. The current revolution largely justifies the forecast of D. Bell, an author of the theory of post-industrial development, about the transition from the world of technology to the world of people. The human is the main subject and object of the changes. In this regard, we review an interdisciplinary program on human research, initiated in the 1980s by I.T. Frolov. The ongoing scientific revolution in genetics and the transition to autoevolution make these ideas even more relevant. The concept of universal evolutionism proposed by N.N. Moiseev is fundamental. This concept originates from philosophical and methodological generalizations based on the vast experience of computer modeling of “human-dimensional” systems. The principles of co-evolution of man and biosphere, the strategies for finding compromises are very close to the ecology of technologies, developed by the theory of HTR. It is difficult to overestimate the importance of the interdisciplinary concept of self-organization for many scientific fields and, in particular, for the theory of HTR. In our days, proposed by an outstanding mathematician, methodologist and thinker S.P. Kurdyumov, the interpretation of synergetics as a bridge between humanities and natural science, as a common language of natural scientists, mathematicians, scholars has become generally accepted. Kurdyumov predicted that many concepts and ideas of synergetics, through their philosophical understanding, would change the outlook and become an element of scientific culture. We show that this forecast turns into reality and in the process of HTR the ideas of synergetics begin to change our world. We pay special attention to the concept of self-developing systems, the theory of global scientific revolutions and the types of scientific rationality proposed by V.S. Stepin. In this regard, we can say that the HTR brings even more large-scale changes, covering not only science but also technology, society, the inner world of man. Identifying the philosophical foundations of HTR, we contribute to the development of methodology of this approach, enhance intra-scientific reflection and make possible to formulate unsolved problems more accurately. (shrink)

Монография посвящена анализу и описанию феномена актуального членения предложения как текстовой и как языковой реальности. Подробно на примерах описывается комплекс языковых средств ремовыделения в португальском и русском языках.

Plava predavanja -- Plavo i Ultravioletno -- Slovo o Nostalgiji.

The Greek Prophetologion manuscript Q12 from the library of the Academy of Sciences in St. Petersburg, copied in 1275, contains some thirty marginal notes written in Alanic, a pre-stage of Ossetic. On leaf 100r, the glossator provided the Greek heading τ παραμο(ν) τς μέ(σο) ν´ (i.e. μεσοπεντηκοστς), ‘Eve of Mid-Pentecost’, with a gloss πητζινάκ χουτζάου πάν which most probably means ‘Pecheneg Sunday’. A Pecheneg festival established after the decisive victory of John II over the Pechenegs is attested by both Nicetas (...) Choniates and Ecloga Basilicorum. It is no wonder that this festival reached distant Alania, since the 12th century was a heyday for the Orthodox Christianity in the Northern Caucasus. The battle took place near Beroea in spring of the “fifth year” of John II's reign. The majority of historians tend to opt for 1122, but we would not exclude 1123 either. Whatever the year, the marginal note from Q12 may help in establishing the day of the battle, which is not mentioned either in Greek or in Scandinavian sources. If the battle of Beroea took place in 1122, it happened either on the 20th–22nd or on the 24th–26th of April. If the battle was fought in 1123, the day of the victory could then be either the 10th–12th or the 14th–16th of May. (shrink)

This paper tackles an old, yet persisting philosophical and cultural imaginary that justifies the political subjugation, marginalization and exclusion of distant others through claims that such people are less advanced and cognitively inferior, and therefore remain at the periphery of moral and political considerations of Western political culture. My premise here is that all knowledge is historically conditioned, and as such serves as a discursive formation that mirrors and sustains specific historical forms of social organization and practices. Thus, by considering (...) the interrelated themes of epistemic and social inclusion of refugees and migrants from a range of critical philosophical perspectives, I argue that successfully managing the dire humanitarian circumstances involved in admitting and receiving displaced and migrant people requires the inclusion of both the bodies of knowledge and discursive interactions and also diverse social and cultural perspectives. (shrink)

One of the most important exponents of the School of Alexandria, Clement of Alexandria (ca. 150. – ca. 215.) is the author of a famous trilogy, consisting of Protrepticus, Paedagogus, and Stromata, which correspond to the three ways of acting of the Logos, namely to convert the pagans to the true faith, to cure the soul from passions, and to uplift the soul to the methodic and intellectual life of spiritual perfection. Logos thus acts through exhortation, training, and teaching. Clement (...) considers himself to be the guardian of the Apostolic tradition and takes the task of conserving this tradition, which consists of cosmological and theological truths. With that goal in mind, the Alexandrian talks about the relation between pagan philosophy and Christianity, allegorical interpretation of the Scripture, the need of revealing and concealing the knowledge, which, in order to be correctly understood, has to be interpreted in accordance with the tradition. The intention of this short article is to point out these concepts and their connections in the way Clement sees them. (shrink)

This paper explores the ethical challenges involved in the ways public representation structures our experiences of atrocities and facilitates an adequate awareness of and response towards the suffering of others. It points out that such an analysis should not exhaust itself in answering what makes public representations of human suffering ethically suspicious and intolerable, but should rather extend this task by clarifying how the public forms sentiments about their social and political reality by elucidating under which conditions public representation promotes (...) broader political agendas. One of the central tenets of human rights advocacy is the widespread conviction that exposure to images and stories of human rights abuse has a mobilizing effect on western audience whose exposure to such knowledge can motivate them to intervene and prevent future atrocities. In order to assess the basic implications of such a conviction we must answer at least three principal clusters of questions. First, how do public representations of atrocities affect individuals and their capacities to conceive and respond to social injustices and the suffering of others? Under what circumstances may agents respond effectively to shocking content? Second, how do social powers operate within the field of perception in order to control how the viewing public is affected? And how do these effects inform and galvanize political support or opposition regarding concrete historical events? Finally, what can be said about the responsibilities of visual representation? Whose agency is it that images inform, and what reforms are necessary to make representations of suffering ethically effective means to encourage better acknowledgment of individual and collective responsibilities that would motivate the public to meet its moral and political obligations? This paper ultimately suggests that in order for politically implicated images to have an immediate critical effect on individuals and their agency, they need to cultivate alternative modes of perception.Article first published online: 21 DEC 2015. (shrink)

In some recent work on omissions, it has been argued that the causal theory of action cannot account for how agency is exercised in intentionally omitting to act in the same way it explains how agency is exercised in intentional action. Thus, causalism appears to provide us with an incomplete picture of intentional agency. I argue that causalists should distinguish causalism as a general theory of intentional agency from causalism as a theory of intentional action. Specifically, I argue that, while (...) intentional actions may best be understood as the causal products or outcomes of causings, we should identify exercises of intentional agency with causal processes. With a causalist account of intentional agency sketched, I respond to the challenge to causalism from omissions. I argue that when an agent intentionally omits there is a causal process that has a zero-sum outcome. But the causal process is sufficient to make it true that the agent exercises intentional agency in intentionally omitting. (shrink)

In her recent paper, “A Defense of Substance Causation,” Ann Whittle makes a case for substance causation. In this paper, assuming that causation is a generative or productive relation, I argue that Whittle’s argument is not successful. While substances are causally relevant in causal processes owing to outcomes being counterfactually dependent upon their role in such occurrences, the real productive work in causal processes is accomplished by the causal powers of substances.

Viebahn (2018) has recently argued that several tests for ambiguity, such as the conjunction-reduction test, are not reliable as tests for polysemy, but only as tests for homonymy. I look at the more fine-grained distinction between regular and irregular polysemy and I argue for a more nuanced conclusion: the tests under discussion provide systematic evidence for homonymy and irregular polysemy but need to be used with more care to test for regular polysemy. I put this conclusion at work in the (...) context of the debate over the alleged referential-attributive ambiguity of the definite article. In reply to various criticisms, defenders of the ambiguity view argue that this is a case of polysemy. But opponents object that the dual use of the definite article fails tests for ambiguity. The debate seems to have come to stalemate, unless the relevance of the tests is determined for cases of alleged polysemy. I conclude that the balance of considerations incline towards rejecting the ambiguity thesis. (shrink)

ABSTRACT: Defending the distinction between believing and accepting a proposition, I argue that cases where agents allegedly exercise direct voluntary control over their beliefs are instances of agents exercising direct voluntary control over accepting a proposition. The upshot is that any decision to believe a proposition cannot result directly in one’s acquiring the belief. Accepting is an instrumental mental action the agent performs that may trigger belief. A model of the relationship between acceptance and belief is sketched and defended. The (...) consequences of the distinction between belief and acceptance, and the model of belief control sketched are then applied to the recent case made by Carl Ginet in defense of the conceptual and psychological possibility of agents exercising direct voluntary control over their beliefs. n. (shrink)